SNPiP（非神経性心臓コリン作動系誘導薬）による、心臓保護作用増強効果に関するトランスクリプトーム解析の研究　心臓拡張能亢進による心機能改善のメカニズム

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授乳期の高メチル食給餌は子孫のストレス曝露後の糖質コルチコイド値を正常化する
ーモデルラットを用いた実験からー

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研究業績 (2019～2023)

＜2023＞

Takenaka, Y., Inoue, I., Hirasaki, M., Ikeda, M., Kakinuma, Y. "Temporal inhibition of the electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts", FEBS Journal, vol. 290(15), pp. 3843-3857, 2023

Haga, N., Usui, T., Takenaka, Y., Chiba, Y., Abe, T. "Immaturin-Nuclease as a Model System for a Gene-Programmed Sexual Development and Rejuvenescence in Paramecium Life History", Microorganisms, vol. 11(1), 82; https://doi.org/10.3390/microorganisms11010082, 2023

＜2022＞

Yamaguchi N, Kakinuma Y, Yakura T, Naito M, Okada S. Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats. Auton Neurosci. 2022;239:102957.

Takenaka Y, Inoue I, Nakano T, Ikeda M, Kakinuma Y. Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and subsequent mitochondrial accumulation in human fibroblasts. FEBS J. 2022;289:1650-1667.

Kurabayashi A, Furihata K, Iwashita W, Tanaka C, Fukuhara H, Inoue K, Furihata M, Kakinuma Y. Murine remote ischemic preconditioning upregulates preferentially hepatic glucose transporter-4 via its plasma membrane translocation, leading to accumulating glycogen in the liver. Life Sci. 2022;290:120261.

Maruyama T, Mano A, Ishii T, Kakinuma Y, Kaneda M. P2X₂ receptors supply extracellular choline as a substrate for acetylcholine synthesis. FEBS Open Bio. 2022;12:250-257.

＜2021＞

Nemoto T, Kakinuma Y. Prenatal and Postnatal Methyl-Modulator Intervention Corrects the Stress-Induced Glucocorticoid Response in Low-Birthweight Rats. Int J Mol Sci. 2021 Sep 9;22(18):9767.

Nemoto T, Ando H, Nagao M, Kakinuma Y, Sugihara H. Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats. Front Endocrinol (Lausanne). 2021;12:694336.

Kakinuma Y. Characteristic effects of the cardiac non-neuronal acetylcholine system augmentation on brain functions. Int J Mol Sci. 2021;22(2):545.

Kakinuma Y. Significance of vagus nerve function in terms of pathogenesis of psychosocial disorders. Neurochem Int. 2021;143:104934.

Sugama S, Kakinuma Y. Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response. Neurochem Int. 2021;143:104943.

Oikawa S, Kai Y, Mano A, Ohata H, Kurabayashi A, Tsuda M, Kakinuma Y. Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart. J Physiol Sci. 2021;71(1):2.

Saw EL, Pearson JT, Schwenke DO, Munasinghe PE, Tsuchimochi H, Rawal S, Coffey S, Davis P, Bunton R, Van Hout I, Kai Y, Williams MJA, Kakinuma Y, Fronius M, Katare R. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovasc Diabetol. 2021;20(1):50.

Nakano T, Aochi H, Hirasaki M, Takenaka Y, Fujita K, Tamura M, Soma H, Kamezawa H, Koizumi T, Shibuya H, Inomata R, Okuda A, Murakoshi T, Shimada A, Inoue I. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Dev Biol 2021;478:222-235

＜2020＞

Sugama S, Kakinuma Y. Stress and brain immunity: Microglial homeostasis through hypothalamus-pituitary-adrenal gland axis and sympathetic nervous system. Brain Behav Immun Health 2020;7:100111.

Oikawa S, Kai Y, Mano A, Nakamura S, Kakinuma Y. S-Nitroso-N-Pivaloyl-D-Penicillamine, a novel non-neuronal ACh system activator, modulates cardiac diastolic function to increase cardiac performance under pathophysiological conditions. Int Immunopharmacol. 2020;84:106459.

Kurabayashi A, Iwashita W, Tanaka C, Naganuma S, Furihata M, Inoue K, Kakinuma Y. Murine remote ischemic preconditioning suppresses diabetic ketoacidosis by enhancing glycolysis and entry into tricarboxylic acid cycle in the liver. Life Sci. 2020;253:117748.

Nemoto T, Nakakura T, Kakinuma Y. Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels due to abnormal pituitary negative feedback. PLoS One. 2020 Aug 27;15(8):e0238223.

Nemoto T, Kakinuma Y. Fetal malnutrition-induced catch up failure is caused by elevated levels of miR-322 in rats. Sci Rep. 2020 Jan 28;10(1):1339.

Yazawa T, Imamichi Y, Uwada J, Sekiguchi T, Mikami D, Kitano T, Ida T, Sato T, Nemoto T, Nagata S, Islam Khan MR, Takahashi S, Ushikubi F, Suzuki N, Umezawa A, Taniguchi T. Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation. J Steroid Biochem Mol Biol 2020;196:105493

Nakano T, Inoue I, Takenaka Y, Ito R, Kotani N, Sato S, Nakano Y, Hirasaki M, Shimada A, Murakoshi T. Ezetimibe impairs transcellular lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells. Biochim Biophys Acta Mol Cell Biol Lipids 2020;1865:158808

Inoue I, Takenaka Y, Kin Y, Yamazaki S, Ikegami Y, Saito D, Shimada A. A sudden onset of severe thrombocytopenia while using Evolocumab. Case Rep Hematol 2020;2020:3281626

Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T. Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling. Free Radic Biol Med 2020;156:45-56

Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Waragai M, Masliah E, Takenouchi T. Understanding Creutzfeldt-Jackob disease from a viewpoint of amyloidogenic evolvability. Prion 2020;14時1分-8

Ho G, Takamatsu Y, Wada R, Sugama S, Waragai M, Takenouchi T, Masliah E, Hashimoto M. Connecting Alzheimer's disease with diabetes mellitus through amyloidogenic evolvability. Front Aging Neurosci 2020;12:576192

Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Adiponectin paradox in Alzheimer's Disease; relevance to amyloidogenic evolvability? Front Endocrinol (Lausanne) 2020;11:108

＜2019＞

Sugama S, Takenouchi T, Hashimoto M, Ohata H, Takenaka Y, Kakinuma Y. Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation. J Neuroinflammation. 2019;16(1):266.

Oikawa S, Kai Y, Mano A, Sugama S, Mizoguchi N, Tsuda M, Muramoto K, Kakinuma Y. Potentiating a non-neuronal cardiac cholinergic system reinforces the functional integrity of the blood brain barrier associated with systemic anti-inflammatory responses Brain Behav Immun 2019;81:122-137.

Oikawa S, Kai Y, Mano A, Nakamura S, Kakinuma Y. A novel nitric oxide donor, S-nitroso-N-pivaloyl-D-penicillamine, activates a non-neuronal cardiac cholinergic system to synthesize acetylcholine and augments cardiac function. Cell Physiol Biochem 2019;52:922-934.

Sato T, Nemoto T, Hasegawa K, Ida T, Kojima M. A new action of peptide hormones for survival in a low-nutrient environment Endocr J 2019;66:943-952

Takamatsu Y, Ho G, Waragai M, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M Transgenerational interaction of Alzheimer's disease with Schizophrenia through amyloid evolvability. J Alzheimers Dis 2019;68:473-481

Ho G, Takamatsu Y, Waragai M, Wada R, Sugama S, Takenouchi T, Fujita M, Ali A, Hsieh MH, Hashimoto M. Current and future clinical utilities of Parkinson's disease and dementia biomarkers: can they help us conquer the disease? Expert Rev Neurother 2019;19:1149-1161

Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E. Possible role of amyloid cross-seeding in evolvability and neurodegenerative disease. J Parkinsons Dis 2019;9:793-802